槲皮素抗宫颈癌作用机制的研究进展

doi:10.12280/gjfckx.20250453

摘要/Abstract

摘要：

槲皮素是一种从中草药中提取的黄酮类化合物，其分布广泛，对良恶性肿瘤具有较好的疗效。槲皮素抗宫颈癌的作用机制包括调控转化生长因子β1（transforming growth factor-β1，TGF-β1）从而抑制细胞增殖；下调基质金属蛋白酶-9（matrix metalloproteinase-9，MMP-9）表达从而抑制细胞侵袭与迁移；促进氧化应激、激活p53基因、激活内质网应激、激活AMP活化的蛋白质激酶（AMP-activated protein kinase，AMPK），从而促进细胞凋亡；通过阻滞细胞周期、下调B细胞淋巴瘤-2（B-cell lymphoma 2，Bcl-2）/Bcl-2相关X蛋白（Bcl-2 associated X protein，Bax）比值等增加放射敏感性；通过调控凋亡因子的表达等增加化疗敏感性；通过干预磷脂酰肌醇3激酶（phosphoinositide 3-kinase，PI3K）/蛋白激酶B（protein kinase B，Akt）、Wnt/β-联蛋白（β-catenin）、Janus激酶2（Janus kinase 2，JAK2）/信号转导及转录活化因子3（signal transducer and activator of transcription 3，STAT3）等信号通路发挥抗宫颈癌作用。槲皮素在宫颈癌治疗领域有广阔的应用前景。然而，槲皮素的临床应用仍面临水溶性差、生物利用度低等限制，未来需要从基础研究到临床应用的多个层面进行深入探索，明确剂量-反应关系，规范用药方案标准，以期为宫颈癌的治疗提供更有效的策略。

关键词: 槲皮素, 宫颈肿瘤, 细胞增殖, 肿瘤浸润, 治疗

Abstract:

Quercetin is a flavonoid compound extracted from Chinese herbal medicine. It is widely distributed and has good therapeutic effects on both benign and malignant tumors. The mechanisms of quercetin against cervical cancer include: inhibiting cell proliferation by suppressing transforming growth factor-β1 (TGF-β1); inhibiting cell invasion and migration by down-regulating the expression of matrix metalloproteinase-9 (MMP-9); promoting cell apoptosis by promoting oxidative stress, activating the p53 gene, activating endoplasmic reticulum stress, and activating AMP-activated protein kinase (AMPK); increasing radiosensitivity by arresting the cell cycle and down-regulating the ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein (Bax); increasing chemosensitivity by regulating the expression of apoptotic factors; and exerting anti-cervical cancer effects by interfering with signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), Wnt/β-catenin, and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3). Quercetin has broad application prospects in the field of cervical cancer treatment. However, the clinical application of quercetin is still limited by poor water solubility and low bioavailability. In the future, in-depth exploration is needed at multiple levels from basic research to clinical application to clarify the dose-response relationship and standardize the medication regimen, aiming to provide more effective strategies for the treatment of cervical cancer.

Key words: Quercetin, Uterine cervical neoplasms, Cell proliferation, Neoplasm invasiveness, Therapy

张丽倩, 王宇, 高越, 白宇鑫, 范芮睿, 谢久梅, 吴效科. 槲皮素抗宫颈癌作用机制的研究进展[J]. 国际妇产科学杂志, 2025, 52(4): 425-430.

ZHANG Li-qian, WANG Yu, GAO Yue, BAI Yu-xin, FAN Rui-rui, XIE Jiu-mei, WU Xiao-ke. Research Progress on the Mechanism of Quercetin against Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2025, 52(4): 425-430.

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