关键词: 宫颈肿瘤, 妇科外科手术, 化学疗法, 辅助, 局部晚期宫颈癌, 同步放化疗

Abstract: Cervical cancer is one of malignant tumors which causes serious threat to women. Treatment for locally advanced cervical cancer （LACC） has being controversial because of its large lesions, operation difficulty and poor prognosis. Radical concurrent chemoradiotherapy, radical surgery and chemoradiotherapy plus hysterectomy are mainly recommended. In clinical treatments, due to the regional differences in radiotherapy levels and individual differences, the treatments of LACC still exhibit diversity. The therapeutic ratio of prophylactic semiextended field intensity-modulated radiation therapy is similar to conventional prophylactic extended-field radiotherapy, while the former reduces the incidence of toxicity. Chemoradiotherapy plus hyperthermia is well tolerated and causes no additional acute or long-term toxicity compared with chemoradiotherapy alone. There is no significant evidence indicates that para-aortic lymphadenectomy has a positive impact on overall survival in LACC, but it′s useful to predict the prognosis and related to better overall survival in patients with common iliac lymph node metastasis. Pelvic external beam radiotherapy with chemotherapy followed by type Ⅰ extra-fascial hysterectomy can be a good alternative for patients who cannot have no access to successful intracavitary brachytherapy.

Key words: Uterine cervical neoplasms, Gynecologic surgical procedures, Chemotherapy, adjuvant, Locally advanced cervical cancer, Concurrent chemoradiotherapy