国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (1): 25-28.

• 综述 • 上一篇    下一篇

vaspin与妊娠期糖尿病的研究现状

唐宇平,应豪   

  1. 200040 上海,同济大学附属第一妇婴保健院产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-02-15 发布日期:2016-02-15
  • 通讯作者: 应豪

The Research Status of Vaspin and Gestational Diabetes Mellitus

TANG Yu-ping,YING Hao   

  1. Department of Obstetrics,Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine,Shanghai 200040,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-02-15 Online:2016-02-15
  • Contact: YING Hao

摘要: 妊娠期糖尿病是指在妊娠期首次发生或发现不同程度的糖代谢异常的一种内分泌疾病,其是严重威胁母儿健康的妊娠期常见并发症,其发病机制复杂,近年研究表明脂肪细胞因子分泌异常导致胰岛素抵抗增加可能是妊娠期糖尿病的发病机制之一。内脏脂肪特异性丝氨酸蛋白酶抑制剂(visceral adipose tissue-derived serine protease inhibitor,vaspin)是新近发现的脂肪细胞因子,具有增加胰岛素敏感性,改善胰岛素抵抗等作用,与2型糖尿病及妊娠期糖尿病的关系密切,可能在妊娠期糖尿病的发生、发展中发挥重要作用。目前已有部分关于vaspin与妊娠期糖尿病关系的研究,但结果差异较大。本文综述vaspin在妊娠期的变化及其与妊娠期糖尿病的研究现状。

关键词: 内脏脂肪特异性丝氨酸蛋白酶抑制剂, 糖尿病, 妊娠, 胰岛素抗药性, 脂肪因子类, 脂肪组织

Abstract: Gestational diabetes mellitus(GDM) is defined as an endocrine metabolic disease with glycometabolism disorder in varied degrees which firstly occur or is identified during pregnancy. It is a serious but common threat to the health of mother and fetal. Recent research shows that increased insulin resistance(IR) caused by abnormal adipose cytokines secretion might be one of the pathogenesis of GDM. Vaspin(visceral adipose tissue-derived serine protease inhibitor), as a newly discovered adipose cytokines with insulin-sensitizing and improving insulin resistance effects, probably plays an important role in the development of type 2 diabetes and GDM. Recently, there are some researches between vaspin and GDM, but the results are different. This review is aimed to summarize the change of vaspin during pregnancy and the relationship between vaspin and GDM.

Key words: Vaspin, Diabetes, gestational, Insulin resistance, Adipokines, Adipose tissue