国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (1): 76-78.

• 论著 • 上一篇    下一篇

降低米非司酮和米索前列醇剂量催经止孕效果观察

郭丽娜 苏 婧 顾向应   

  1. 300052 天津医科大学总医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-02-15 发布日期:2011-02-15

Study on Rreducing Dose of Mifepristone Combined with Misaprontol for Menstrual Regulation

GUO Li-na, SU Jing, GU Xiang-ying   

  1. Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital,Tianjin 300052,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-02-15 Online:2011-02-15

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摘要： 目的：观察降低米非司酮与米索前列醇剂量催经止孕的临床效果。方法：将120例闭经时间≤37 d的妇女随机分为2组（各60例）。低剂量组：给予米非司酮100 mg口服，米索前列醇400 μg舌下含服；常规剂量组：给予米非司酮150 mg，米索前列醇600 μg口服。比较给药后2组的完全流产率、出血时间、平均流产时间和不良反应的程度。结果：测定血清人绒毛膜促性腺激素β亚单位（β-hCG）诊断低剂量和常规剂量组分别有3例和2例未妊娠，给药后均引发阴道出血（即月经来潮）。2组完全流产率、出血时间差异无统计学意义（P ＞0.05）；常规剂量组平均流产时间短于低剂量组（P ＜0.05）；低剂量组不良反应发生率低于常规剂量组 （P ＜0.05）。结论：降低米非司酮和米索前列醇剂量用于闭经≤37 d催经止孕可行，且不良反应少。

关键词: 米非司酮, 米索前列醇, 药物疗法, 联合, 月经, 堕胎药, 流产, 人工

Abstract: Objective: To study clinical efficacy of lower dose of mifepristone combined with misoprostol. Methods: 120 women with amenorrhea less than 37 days for 2 groups randomly. Sixty women in group of lower dosage （experimental group）: these women were dosed with mifepristone 100 mg for oral taken and oral cavity misoprostol 0.4 mg for sublingual taken. Sixty women in group of conventional dosage（control group）: these women were dosed with mifepristone 150 mg and misoprostol 0.6 mg for oral taken. Under the premise of reducing the mifepristone and misoprostol dosage, check the women′s complete abortion rate, bleeding time after taking medicine, abortion time and side effects to see if they were superior than conventional scheme. Results: Three women and 2 women were not pregnant confirmed by serum hCG test in group of lower dosage and group of conventional dosage, vaginal bleeding（i.e. the menses）appeared after they took the medicine.There was no obvious difference in complete abortion rate of group of lower dosage and group of conventional dosage（P > 0.05）. Mean abortion time of group of conventional dosage was superior than that of group of lower dosage（P <0.05）; there was no obvious difference in bleeding time of group of lower dosage and group of conventional dosage after dosing（P > 0.05）. Side effects in group of lower dosage and group of conventional dosage were significant difference（P < 0.05）.Conclusion: Effect of mifepristone with misoprostol in small dosage for amenorrhea ≤37 d women′s hastening menses and preventing pregnancy was feasible and side effects were less.

Key words: Mifepristone, Misoprostol, Drug therapy, combination, Menstruation, Abortifacient agents, induced