白藜芦醇在子痫前期中的作用机制及研究进展

doi:10.12280/gjfckx.20201129

摘要/Abstract

摘要：

子痫前期是起源于胎盘功能障碍的全身炎性多系统综合征,严重威胁母婴健康。白藜芦醇（Resveratrol）是一种抗衰老、抗氧化应激、抗炎、诱导细胞凋亡和增强胰岛素敏感性的天然多酚化合物。研究表明,白藜芦醇通过抑制氧化应激,抵抗炎症,调节血管功能,促进滋养细胞侵袭,调节免疫功能等在子痫前期的病理生理过程中发挥有效作用。综述白藜芦醇在子痫前期的潜在作用机制及其研究进展,为白藜芦醇进一步在子痫前期的研究和应用提供参考。

关键词: 先兆子痫, 氧化性应激, 抗氧化剂, 白藜芦醇

Abstract:

Pre-eclampsia is a systemic inflammatory multi-system syndrome originating from placental dysfunction,which seriously threatens the health of both mothers and infants. Resveratrol is a natural polyphenol compound that shows effects on anti-aging, anti-oxidative stress, anti-inflammatory, inducing cell apoptosis and enhancing insulin sensitivity. Resveratrol plays an effective role in the pathophysiological process of pre-eclampsia by inhibiting oxidative stress, resisting inflammation, regulating vascular function, promoting trophoblast cell invasion, and regulating immune function. This article summarizes the potential therapeutic mechanism of Resveratrol in pre-eclampsia, and provides reference for the further research and application of Resveratrol in pre-eclampsia.

Key words: Pre-eclampsia, Oxidative stress, Antioxidants, Resveratrol

文清, 柒铭铭, 赖慧敏, 谢恺俐, 王铭远. 白藜芦醇在子痫前期中的作用机制及研究进展[J]. 国际妇产科学杂志, 2021, 48(4): 371-375.

WEN Qing, QI Ming-ming, LAI Hui-min, XIE Kai-li, WANG Ming-yuan. The Mechanism and Research Progress of Resveratrol in Pre-eclampsia[J]. Journal of International Obstetrics and Gynecology, 2021, 48(4): 371-375.

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