代谢组学技术在稽留流产研究中的应用

doi:10.12280/gjfckx.20221051

摘要/Abstract

摘要：

代谢组学是通过全面、定量检测生物系统中内源性的小分子化合物，来了解生物体内某一时刻所有内源性代谢物的变化，筛选出显著性生物标志物，为疾病的早期预测、诊断及探索发病机制提供新思路。稽留流产是一种常见的妇科疾病，其发病机制尚未完全阐明。目前，已有代谢组学技术应用于稽留流产的研究，发现可能与稽留流产相关的生物标志物，涉及三羧酸循环、氧化应激及信号转导等多种通路，取得了进展性突破。综述代谢组学技术及其在稽留流产研究中的应用，并进一步探讨血清中的差异代谢物和相关代谢通路的改变对稽留流产的影响。

关键词: 流产, 稽留, 代谢组学, 生物标记, 血清, 血浆

Abstract:

Metabolomics is a technology which understands the changes of all endogenous metabolites in the organism at a certain time through comprehensive and quantitative detection of endogenous small molecular compounds in the biological system, screening out significant biomarkers, and providing new ideas for early prediction, diagnosis and exploration of pathogenesis of diseases. Missed abortion is a common gynecological disease, and its pathogenesis has not been fully elucidated. At present, metabonomics technology has been applied to the study of missed abortion, and biomarkers that may be associated with missed abortion have been found, involving a variety of pathways such as tricarboxylic acid cycle, oxidative stress and signal transduction, making a breakthrough. This article briefly introduces the metabonomics technology and its application in the study of missed abortion, and to further discusses the explore of differential metabolites in serum and changes in related metabolic pathways on missed abortion.

Key words: Abortion, missed, Metabolomics, Biomarkers, Serum, Plasma

夏丽娜, 单莉, 赵欢, 楚光华, 王燕霞. 代谢组学技术在稽留流产研究中的应用[J]. 国际妇产科学杂志, 2023, 50(3): 322-326.

XIA Li-na, SHAN Li, ZHAO Huan, CHU Guang-hua, WANG Yan-xia. Application of Metabonomics in the Study of Missed Abortion[J]. Journal of International Obstetrics and Gynecology, 2023, 50(3): 322-326.

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