子痫前期中氧化应激对蛋白质翻译后修饰的影响机制

doi:10.12280/gjfckx.20260264

摘要/Abstract

摘要：

异常氧化应激是子痫前期（preeclampsia，PE）胎盘的关键病理特征之一，并影响滋养层功能表达及免疫平衡，蛋白质翻译后修饰（post-translational modifications，PTMs）是蛋白质在翻译后发生的一系列共价修饰，PE中现已发现众多类别PTMs，且氧化应激广泛参与其中。氧化应激可通过直接损伤蛋白、调节修饰酶活性及代谢物水平等方式调控PTMs，协调PE中的PTMs，同时PTMs也会影响细胞氧化应激状态，两者之间相互调节，共同参与胎盘氧化应激调节和胎盘功能表达。但PE中细胞氧化代谢复杂及各PTMs间存在相互协调作用、氧化应激影响PTMs的方式及其对PE发病的调控机制仍不清楚。综述氧化应激通过调控各修饰酶活性和表达水平对PE中蛋白质磷酸化、泛素化、乙酰化和乳酸化等翻译后修饰的影响，概述糖代谢和乳酸水平对胎盘氧化应激状态及功能表达的影响。

关键词: 氧化性应激, 先兆子痫, 蛋白质加工, 转译后, 泛素化, 乙酰化作用, 磷酸化, 乳酸化

Abstract:

Abnormal oxidative stress is a one of the key pathological features of the placenta in preeclampsia (PE) and affects trophoblast function and immune balance. Post-translational modifications (PTMs) refer to a series of covalent modifications occurring after protein translation. Numerous categories of PTMs have been identified in PE, and oxidative stress is extensively involved. Oxidative stress can regulate PTMs through direct protein damage, modulation of modifying enzyme activity, and alterations in metabolite levels, thereby coordinating PTMs in PE. Simultaneously, PTMs can influence cellular oxidative stress status. The two mutually regulate each other and jointly participate in placental oxidative stress regulation and placental function. However, the complexity of cellular oxidative metabolism in PE, the interactions among various PTMs, the mechanisms by which oxidative stress affects PTMs, and its regulatory role in PE pathogenesis remain unclear. This review summarizes the impact of oxidative stress on protein phosphorylation, ubiquitination, acetylation, lactylation, and other PTMs in PE by regulating the activity and expression levels of modifying enzymes. It also outlines the influence of glucose metabolism and lactate levels on placental oxidative stress status and function.

Key words: Oxidative stress, Pre-eclampsia, Protein processing, post-translational, Ubiquitination, Acetylation, Phosphorylation, Lactylation

王军, 朱静蕾, 蒲瑞阳, 李水利, 孙晓彤. 子痫前期中氧化应激对蛋白质翻译后修饰的影响机制[J]. 国际妇产科学杂志, 2026, 53(4): 447-451.

WANG Jun, ZHU Jing-lei, PU Rui-yang, LI Shui-li, SUN Xiao-tong. Mechanisms of Oxidative Stress Impact on Protein Post-Translational Modifications in Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2026, 53(4): 447-451.

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