国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (2): 164-166.

• 综述 • 上一篇    下一篇

子痫前期致子代胚胎源性疾病的研究现状


胡文胜，吴再归，黄荷凤   

  1. 310006 杭州，浙江大学医学院附属妇产科医院产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-04-15 发布日期:2014-04-15
  • 通讯作者: 黄荷凤

Current Opinion in Fetal Origins of Adult Disease from Preeclampsia

HU Wen-sheng，WU Zai-gui，HUANG He-feng   

  1. Department of Obstetrics, Women′s Hospital，School of Medicine，Zhejiang University，310006 Hangzhou，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-04-15 Online:2014-04-15
  • Contact: HUANG He-feng

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摘要： 胚胎源性疾病也即胎儿起源的成人疾病，主要指胚胎发育过程中基于环境因素，特别是营养因素的作用，在生命早期形成的成年后患病的风险。胎盘在宫内营养环境的编程中发挥重要作用。子痫前期尤其是早发型子痫前期的发生，与胎盘异常密切相关。大量流行病学及动物实验也证实，子痫前期与子代高血压、糖尿病及脑卒中等成人疾病的发生密切相关，就子痫前期与子代胚胎源性疾病的关系及机制进行综述。

关键词: 先兆子痫, 胎儿疾病, 妊娠并发症, 高血压, 糖尿病, 卒中

Abstract: Embryonic diseases，that is fetal origins of adult disease states that adverse influences early in development and particularly during intrauterine life can lead to the permanent physiology and metabolic abnormalities，thus subsequently resulting in an increased risk of numerous diseases in adulthood. Placenta plays a critical role in the programme of intrauterine stimulus and preeclampsia，particularly early-onset preeclampsia was closely related to the placenta insufficiency. Increasing evidences from epidemiology and experiments on animals have proven that the development of adult diseases such as hypertension，diabetes and stroke was strongly linked with preeclampsia. This article would state the relationship and the potential mechanism among them.

Key words: Pre-eclampsia, Fetal diseases, Pregnancy complications, Hypertension, Diabetes mellitus, Stroke