Combination of Immunity and Targeted Therapy: A New Perspective on the Treatment of Endometrial Carcinoma

doi:10.12280/gjfckx.20210290

Abstract

Abstract:

As one of the three major malignant tumors of female reproductive system, the incidence of endometrial carcinoma is increasing all over the world in recent years. The prognosis of recurrent or metastatic endometrial carcinoma is poor. First-line treatment includes platinum chemotherapy or hormone therapy. There is no standard follow-up therapy at present. In recent years, significant advances have been made in the understanding of the molecular basis of endometrial carcinoma, and potential targets for therapeutic endometrial carcinoma have been identified. Targeted therapy such as PARP inhibitors and immunotherapy such as PD-1/PD-L1 inhibitors may be effective against specific subtypes of endometrial cancer. Clinical studies have shown that the combined use of these drugs may have a synergistic effect. This article reviews the clinical research progress of PD-1/PD-L1 inhibitors and PARP inhibitors in the treatment of endometrial carcinoma.

Key words: Endometrial neoplasms, Molecular targeted therapy, Immunotherapy, Poly(ADP-ribose) polymerases, Antigens,CD274, PD-L1, PD-1

LI Li, LU Xiao-shan, XIN Jia-chun, WANG Xiao-hui. Combination of Immunity and Targeted Therapy: A New Perspective on the Treatment of Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 5-9.

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