Abstract:

With the onset of cancer at a younger age, more and more women of childbearing age are suffering from endometrial cancer. In order to preserve fertility, most patients tend to conservative treatment. Therefore, many researchers have proposed conservative treatment plans for atypical endometrial hyperplasia and early endometrial cancer, and have been clinically studied in small samples. Traditional therapy is mainly oral high-dose progesterone. However, most patients with oral progesterone treatment have high recurrence rate and many complications. Levonorgestrel-releasing intrauterine system can reduce the side effects to the body caused by a large amout of progesterone through local effects on the endometrium. Hysteroscopy can precisely remove the lesion, protect the normal endometrium, and relatively reduce the risk of infertility and miscarriage in the later pregnancy. The anti-tumor effect of metformin can increase the effective rate of progesterone. Now，we summarizing relieving rate, recurrence rate, and pregnancy outcomes of the atypical endometrial hyperplasia and early endometrial cancer after various conservative treatments, in order to evaluate the own factors and disease characteristics of each patient before clinical treatment to choose the most beneficial treatment plan and management model for patients.

Key words: Endometrial neoplasms, Endometrial hyperplasia, Gonadotropin-releasing hormone, Intrauterine devices, medicated, Levonorgestrel, Hysteroscopes