Abstract:

Pelvic floor dysfunctions (PFD) have become a public health problem that is increasingly harmful to women′s health, and its pathogenesis has not yet been fully understood. Because human trials are constrained by medical ethics, animal models are particularly important as a powerful tool for exploring PFD. The current animal models of PFD are roughly divided into rodents, small mammals, large mammals and nonhuman primates according to different species. By researching the status quo, it is found that among the four types of animals, rodent models are the most used, and nonhuman primate models are the most ideal. Simulating childbirth is the primary modeling method and genetic technology can be used to construct animal models with specific properties. Biomechanical measurements provide objective data for the pathology of pelvic floor injury and the evaluation of treatment effects, which can further optimize animal models and will provide more help for exploring the pathogenesis and treatment methods of PFD.

Key words: Pelvic floor, Urinary incontinence, stress, Pelvic organ prolapse, Models, animal, Animal experimentation, Biomechanical phenomena, Pelvic floor dysfunctions