Abstract:

Objective: To explore the impact of different pregnancy methods on the perinatal outcomes of twin pregnancies. Methods: A retrospective analysis was conducted on the clinical data of 815 twin pregnant women who gave birth at the Changsha Maternal and Child Health Hospital affiliated to Hunan Normal University from January 2019 to January 2023. They were divided into a natural pregnancy group (398 cases) and an in vitro fertilization-embryo transfer (IVF-ET) group (417 cases) based on the pregnancy mode. The basic information, pregnancy complications, and perinatal outcomes of the two groups were compared. Results: In IVF-ET group, the age of pregnant women, the gestational week of delivery, the proportion of primiparas, the proportion of polycystic ovary syndrome, the proportion of the dichorionic diamniotic, the incidence of gestational diabetes mellitus, the rate of cesarean section, the amount of postpartum hemorrhage and the rate of postpartum hemorrhage were higher than those in natural pregnancy group, and the proportion of scar uterus was lower than that in the natural pregnancy group (both P<0.05). The premature birth rate and transfer rate to neonatal department in the IVF-ET group were lower than those in the natural pregnancy group, while the birth weight of bigger infants was higher than that in the natural pregnancy group (both P<0.05). Conclusions: The incidence of perinatal complications increases in twin pregnant women who conceive through IVF-ET. It is necessary to strictly grasp the guidelines for embryo transfer, strictly control the number of embryos transferred, strengthen perinatal management, reduce the occurrence of pregnancy complications, and maximize the safety of mother and infant.

Key words: Natural conception, Fertilization in vitro, Embryo transfer, Pregnancy, twin, Pregnancy complications, Pregnancy outcome