Abstract: The animal model used for studying the etiological and therapeutic aspects of endometriosis needs improvement. Previous studies using invasive observation and pathological anatomy showed many disadvantages. In the article, we reviewed literature over the past five years where non-invasive endometriosis animal models were used. The principle, method and the application of each approach is analyzed. The pros and cons of the various kinds of models are listed, with the addition of suggested improvements of methods. This essential information will benefit basic research and the clinical management of endometriosis.

Key words: Endometriosis, In vivo, Noninvasive, Animal model, Fluorescent label