Abstract: The erythropoietin (EPO) is a novel family of angiogenic factors that promote angiogenesis, anti-apoptosis and anti-hypoxia when binding its receptor（EPOR）. The EPO participates in the development of placenta vessels, as well as the angiogenesis and tumor metastasis. EPO and its receptor expressed at reside maternal-fetal interface. Since EPO and its receptor are expressed throughout human gestation, it may play a pivotal role in pregnancy, and their abnormal regulation may be involved in spontaneous abortion, eclampsia and fetal growth restriction. Therefore, EPO in pregnancy may present a novel strategy for treatment of the pregnancy-related diseases.

Key words: Erythropoietin, Angiogenesis, Pregnancy