Abstract: Objective: To evaluate the function of the β-cell in the pregnant women with abnormal GCT and its clinical significance. Methods: A glucose challenge test（GCT） was carried out in all regular examined pregnant women, from 24 to 28 pregnant weeks. If the report was abnormal, they would be required to undergo the oral glucose tolerance test（OGTT）. Then according to the standard of ADA, they were divided into three groups including GDM, GIGT and normality. Then the evaluation of the function of the β-cell was carried out on them. Results: ①HOMA-β of GIGT and NP group were higher than the GDM group, the difference was statistically significant（P <0.0001）. HOMA-IR of NP and GIGT group were lower than the GDM group, the difference was statistically significant（P <0.0001）.②Compared those patients with normal fasting blood glucose between GDM group and GIGT group on the HOMA-β and HOMA-IR, there was no significant difference between the 2 groups. Between GDM group and GIGT group with normal and abnormal fasting blood glucose that the HOMA-β were no significant differences, but HOMA-IR difference was statistically significant. Conclusions: β-cell dysfunction of GIGT women has existed. We must pay attention to these women, especially to the women of fasting glucose impaired. We should provide them rational interventions, reducing the complication of pregnancy and the incidence of T2DM.

Key words: Diabetes, gestational, Multiphasic screening, Glucose tolerance test, Insulin-secreting cells, Insulin resistance