Abstract: Objective: To observe the markers of coagulation—vWF and AT in the pathogenesis of pre-eclampsia and to explore its clinical treatment value. Methods: Using the SYSMEX CA7000 automated hematology analyzer in 27 normal pregnant women and 102 gestational hypertension women to detect the markers, including the part activation thrombin time（APTT）, prothrombin time（PT）, antithrombin （AT），von Willebrand factor（vWF）. Results: ①The activity of AT in the severe eclampsism is lower than that in the mild and the control group. The difference have statistical significance（P ＜0.05）. No statistical significance between the control and mild group（P ＞0.05）. ②The activity of vWF in the severe eclampsism group is higher than that in the mild and the control group, which have statistically significant（P ＜0.05）.No statistical significance between the control and the mild group（P ＞0.05）. ③The differences of PT、APTT、FIB among the control group、the mild group and the severe group are not statistically significant（P ＞
0.05）. ④The AT level of the complications group is significant lower than that of complications group（P ＜0.05）.The
activity of vWF is significantly higher than that of no complications（P ＜0.05）. Conclusions: Monitoring vWF, AT levels contribute to early diagnosis of severe preeclampsia, guide the use of drugs, and improve the prognosis of patient.

Key words: Hypertension, pregnancy-induced, Pre-Eclampsia, Antithrombins, von Willebrand Factor, Thrombin Time