Abstract: Most chorioamnionitis is due to preterm premature rupture of membranes and is closely associated with preterm labor which induces three quarters of newnatal death.So we should pay intensive attention to the presence of chorioamnionitis，especially asymptomatic patients that is often neglected. Based on a large amount of literature， We can see the result about predictive value of chorioamnionitis from tradition bioindicator including erythrocyte sedimentation rate，white blood cell counting and the C-response protein，and from the modern molecular bioindicator including matrix metal proteinase，interleukin，tumor necrosis factor and so on.Serum bioindicators have the advantages of precision，fast and relatively noninvasive method，which is well documented in pregnants by present researchs. By the study of inflammatory cytokines，it is expected to offer new sensitive and available serum biomarkers for the prospective diagnosis of chorioamnionitis.

Key words: Chorioamnionitis, Fetal membranes, premature rupture, Premature birth, Diagnosis, Cytokines