Abstract: Endometriosis（EMs） is a common disease of reproductive-age women. For the high rate of recurrence after conservative surgery, postoperative medication is necessary. The current postoperative medication is various, the currently available agents are not curative, and treatment often needs to be continued for years. Oral contraceptives and progesterone, because of its economic, convenient, less side effects, should be considered as first-line options for post-operative use. Long-term administration of gonadotropin-releasing hormone analogues is expensive, on account of its side effects, its advantage is not obvious, therefore GnRHa is considered as second-line medications with danazol, gestrinone and so on. The levonorgestrel releasing intrauterine systems are particularly suitable for adenomyosis patients. And immunological regulators and gene targeting treatment are new ways for treatment.

Key words: Endometriosis, Drug therapy, Contraceptives, oral, Progestins, Levonorgestrel