Journal of International Obstetrics and Gynecology ›› 2011, Vol. 38 ›› Issue (5): 407-410.

• 综述 • Previous Articles     Next Articles

Molecular Mechanism and Management in Insulin Resistance in Polycystic Ovary Syndrome

SHEN Wen-juan,KUANG Hong-ying,ZHANG Yue-hui,WU Xiao-ke,HOU Li-hui   

  1. Department of Gynecology and Obstetrics,First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: WU Xiao-ke

Abstract: Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorder with a variety of clinical manifestations among women of reproductive age. Its features include chronic anovulation,multicystic morphology of ovaries,hyperandrogenism. In recent years,insulin resistance(IR)has been regarded as one of the mechanisms of the development of PCOS,and is also associated with the hyperandrogenemia and dysfunction of ovaries. Many researches have been done on the molecular mechanism of IR in PCOS,which might provide a theory foundation for the treatment. This review thus focuses on the molecular mechanism and treatment of insulin resistance in patients with PCOS.

Key words: Polycystic ovary syndrome, Insulin resistance, Hyperinsulinism, Glucose clamp technique, Metformin