Journal of International Obstetrics and Gynecology ›› 2011, Vol. 38 ›› Issue (6): 517-519.

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The Established Animal Model of Sequelae of Pelvic Inflammatory Disease

LI Jun-liang,LIU Heng,WANG Jian-liu,WANG Shi-jun,WEI Li-hui   

  1. Department of Obstetrics and Gynecology, Peking University People′s Hospital,Beijing 100044,China(LI Jun-liang now working at the Second Affiliated Hospital of Tsinghua University)
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-12-15 Online:2011-12-15
  • Contact: WANG Jian-liu

Abstract: Objective:to established a rabbit model of sequelae of pelvic inflammatory disease. Methods:Female New Zealand white rabbits of 5-6 months old were studied with an intrauterine insemination catheter for bacterial inoculation for the model of PID. The blood routine,body temperature,body weight were measured. The uterine and oviduct were observed under laparoscopy. The pathological examination of the uterine and oviduct of the rabbits were done in this study. Results:The 5 rabbits were all be inoculated with bacterial successfully. The white blood cell count of the rabbits was increased at the third day and maintened after 14th day of bacterial inoculation. The body weight gain became slowly at 10-20 days,after that showed a steady upward trend. Under laparoscopic observation,edema and exudation were distinguished within 14 days. The tube wall became thickness,thickening,and contracture afterwards. Conclusions:The rabbit model of sequelae of rabbit pelvic inflammatory disease can be established with bacterial inoculation. The rabbit acute pelvic inflammation can be observed within 14 days. The modeling,proliferate and scar repair of rabbit pelvic inflammatory disease are the main changes after two weeks inoculated with bacterial.

Key words: Pelvic inflammatory disease, Rabbits, Disease models, animal, Laparoscopy