Abstract: Objective：To study the association between environmental air pollutants and perineonate mortality and birth defects by respective epidemiololgy investigation. Methods：Obtain the data of perineonate death and birth defects in national control monitor center and air quality data in environmental monitor centre of Tianjin from Jan 2002 to Dec 2007. Analyze the rate of birth defects, fetal death, stillbirth, newborn death within 7 days and induced abortion after gestation of 28 weeks for therapy in different months, seasons, heating-period and non-heating period, city and country. Statistic analysis method is used to study the risk of perineonate death exposed to higher levels of air pollution. Results：The rate of fetal death, stillbirth, newborn death within 7 days and induced abortion after gestation of 28 weeks for therapy in country is significantly higher than that in city（P＜0.001）. There is no significant difference between different seasons, heating and non-heating period（P＞0.05）. The rate of birth defects in spring（Mar, Apr, May）was the highest, while it is the lowest in summer（Jun, Jul, Aug）. Conclusions：Long-term malignant accumulated air pollutants exposure would increase the risk of birth defects and perineonate death. It is suggested that women who have high risk of abortion should not be pregnant in heating period with serious air pollution.

Key words: Air pollution, Perinatology, Fetal death, Congenital abnormalities, Retrospective studies