Abstract: Polycystic ovarian syndrome（PCOS） is a heterogeneous and polymorphic endocrine disease. Studies have
shown that patients with PCOS had a higher incidence of thyroid disease. Earlier studies mainly consider that women with PCOS can affect the pituitary-thyroid axis，and their immune system was over-stimulated . Recently，new research reveals that genetic variation in the 3′-untranslated region of gonadotropin-releasing hormone receptor is associated with thyroid function in PCOS patients. At the same time， changes in thyroid function can affect ovulation disorders and insulin resistance in women with PCOS.

Key words: Polycystic ovary syndrome, Hypothyroidism, Receptors, gonadotropin, Thyroxine, Insulin resistance