Abstract: Objective： To investigate the impact of high-risk human papillomavirus （HR-HPV） infection fate of mild cervical intraepithelial neoplasia（CIN Ⅰ）， and seek reasonable clinical treatment for CIN Ⅰ. Methods：Select the outpatient women who were diagnozed by pathology for CIN Ⅰ in the Dagang Community Hospital of Tianjin Binhai New Area from January to December in 2010， and divided these women into simple follow-up group and the physical therapy group in accordance with HR-HPV test results and patient wishes of the individual， regular follow-up of TCT and HR-HPV. Results： After 6， 12， and 24-month follow-up， HR-HPV（-） group had no cases of disease progression； HR-HPV（+） group has four cases in cumulative progression； progress physical therapy group has one case of disease progression. Compared HR-HPV（-） group with the HR-HPV（+） group， the difference in disease prognosis between the two groups was statistically significant（P＜0.01）； compared HR-HPV（+） group with the physical therapy group， the rate of disease progression in physiotherapy group was less than HR-HPV（+） group， the difference was statistically significant（P<0.01）. The persistent HR-HPV infection led to the likelihood of progression of CIN Ⅰ. Conclusions： Persistent HR-HPV infection is the risk factors for CIN Ⅰ progression，which should chose a reasonable treatment，the treatment for CIN Ⅰ should be promoted standardizeuy， individualizelly，and humanistically.

Key words: Cervical intraepithelial neoplasia, Papillomaviridae, Therapy