Abstract: Endometrial cancer is one of the most common gynecologic malignancies，and it remains one of the most important causes of mortality in women worldwide. In recent years，the incidence of endometrial cancer has been increased and the age of onset of endometrial cancer has decreased. So it is essential for early diagnosis and treatment of endometrial cancer，but until now，there is still lack of sensitive and specific serological markers. Recent studies have demonstrated that human epididymis protein 4（HE4） was highly expressed in endometrial cancer，and lowly expressed in normal endometrium and benign endometrial lesions. Studies focus on whether HE4 can be used as endometrial cancer early diagnosis and prognosis marker now. This review will briefly summarize the clinical value of HE4 in diagnosis and prognosis of endometrial cancer.

Key words: Tumor markers, biological, Endometrial neoplasms, Sensitivity and specificity, CA-125 antigen, Human epididymis protein 4