Journal of International Obstetrics and Gynecology

Journal of International Obstetrics and Gynecology ›› 2013, Vol. 40 ›› Issue (6): 545-547.

• 综述 • Previous Articles     Next Articles

Role of TLR3 in Cervical Antiviral Immunity and Cervical Lesions

QU Quan-xin，MI Ruo-ran   

  1. Department of Obstetric and Gynecology, Tianjin First Central Hospital，Tianjin 300192，China（QU Quan-xin）；Department of Obstetric and Gynecology, Tianjin Medical University General Hospital，Tianjin 300052，China（MI Ruo-ran）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-12-15 Online:2013-12-15

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Abstract: Toll-like receptor 3（TLR3） is an important member of the family of pattern recognition receptors（PRRs） in innate immunity and can be specific to identify the virus double-stranded RNA，activate the protective response and clean viruses. TLR3 expresses mainly in immune cells and also in epithelial cells and epithelial carcinomas. TLR3 expression is associated with infection，inflammation and tumor progression. Female genital tract mucous membrane is an important barrier against pathogenic microorganism infection，TLR3 expression is associated with genital tract physiology and pathology. The review will discuss the role of TLR3 in cervical HPV persistent infection，intraepithelial neoplasia and cervical cancer.

Key words: Precancerous conditions, Uterine cervical neoplasms, Toll-like receptor 3, Papillomaviridae, Papillomavirus vaccines