Abstract: Objective：To investigate the influence of misoprostol combined with oxytocin on serum levels of angiotensin Ⅱ (AngⅡ) and coagulation factors after parturient postpartum，which is a useful reference for effective treatment of postpartum hemorrhage. Methods：120 parturients with postpartum hemorrhage from our hospital during Dec 2010 to Jan 2013 were included in this study. Those high-risk factors were pregnancy hypertension，placental abruption，placenta previa, fetal macrosomia and multiple pregnancy. Those cases were randomly divided into three groups，each with 40 cases. Parturients in group A were immediately administrated with misoprostol 400 μg through rectum after baby delivery. Parturients in group B were immediately administrated with oxytocin 20 U through palace intramuscular，at the same time，with oxytocin 20 U through intravenous infusion. Parturients in group C were immediately administrated with oxytocin 20 U through palace intramuscular and misoprostol 400 μg through rectum. The postoperative bleeding volume was measured by volum and weight after postpartum 2 h and 24 h. The serum levels of angiotensin and coagulation factors were measured by ELISA. The systolic pressures before childbirth and post partum were observed. Results：There were not significant differences in the serum levels of AngⅡbetween antepartum and postpartum, in both group A and group B（P＞0.05） while this difference was significant in group C（t=7.196，P=0.009）. The same status was found in the serum levels of two coagulation factors in three groups. The hemorrhage volumes post partum 2h, 24h of group A and group B were significantly increased than that of group C （P＜0.05）. The differences of those systolic pressures before childbirth and post partum 2h, in three groups, were not significant （P＞0.05）. Conclusions：Misoprostol combined with oxytocin can significantly increased serum levels of angiotensin and coagulation factors when to treat effectively postpartum hemorrhage.

Key words: Postpartum hemorrhage, AngiotensinⅡ, Factor Ⅷa, Factor Ⅸa, Misoprostol, Oxytocin