Abstract: Hot flush is complained by three out of four perimenopausal women. The exact etiology of hot flush is unclear，which may underline menopausal-associated hypoestrogenism. The altered sympathetic nervous activity and core body temperature adjust mechanism is also related with menopausal-associated hypoestrogenism. Enhanced sympathetic tone may change vascular endothelial dysfunction，blood pressure，lipids and insulin resistance，which are associated with cardiovascular disease （CVD）. Many researches indicate that perimenopausal hot flush is significantly related to CVD .This article reviews the relation between perimenopausal hot flush and CVD，and the guide role to hormone therapy（HT）.

Key words: Perimenopause, Tidal fever, Cardiovascular diseases, Therapy