Abstract: MicroRNAs （miRNA） are a class of highly conserved small，single-stranded non-coding RNAs that regulate target genes expression by fully or partially complementary principle binds to target genes 3′UTRs or direct shear target genes mRNA. miR-17-92 cluster is located on human chromosome 13q31.3，which encodes miR-17，miR-18，miR-19a，miR-20，miR-19b and miR-92. miR-17-92 cluster controls 30 kinds of target genes，which involve in cancer development. The paper reviews the structure and function and the roles of miR-17-92 cluster in gynaecology and other tumors occurrence and development.

Key words: MicroRNAs, Genital neoplasms, female, Multigene family, Genes, tumor suppressor