Abstract: Due to the large changes in specific physiological indicators of thyroid during pregnancy, the gestational thyroid hormone production, circulation, metabolism, regulating and immunity will change according to the different stages of pregnancy. Thyroid hormone is essential for fetal brain development, the deficiency of it seriously affect fetal brain development, in recent years, the incidence of gestational thyroid dysfunction increased significantly, it can lead to adverse pregnancy outcomes. This article reviews the changes of thyroid function on pregnant women and fetus, as well as the incidence of thyroid disorders in pregnant women and the adverse effects on their fetus. The correct diagnosis of thyroid disease and reasonable protection designed to prevent thyroid dysfunction during pregnancy from bringing a series of obstetric complications, and adverse pregnancy outcomes, to avoid affecting the quality of long-term survival of the newborn.

Key words: Pregn, Thyroid disease, Thyroid hormones, Autoantibodies