Abstract: Endometriosis（EMs） is characterized as class neoplastic disease because of its invasiveness，easy to relapse and other neoplastic diseases character. In recent years，with the development of EMs etiology study，the existence of stem cells in the endometrium and these stem cells are involved in the endometrial cyclical activities have been proposed and validated，and then EMs stem cell theory is gradually being recognized. In the research of stem cell as the application of molecular biology method，a growing number of genes and signaling pathways involved in stem cells proved to be take part in stem cell′s cyclical activity，of which Wnt/β-catenin signaling pathway is one of the most important research pathways of stem cells. Wnt/β-catenin signaling pathway is highly conserved in its structural complexity in the development of a variety of tumors by stem cell proliferation cycle play a role，meanwhile Wnt/β-catenin signaling pathway involved in endometrial stem cell regulation，which would provide new ideas for the occurrence, development and treatment of endometriosis.

Key words: Endometriosis, Stem cells, Signal transduction, β-catenin