Abstract: Objective：To investigate the complete androgen insensitivity syndrome （ＣＡＩＳ）, and evaluate the application of laparoscopy in the diagnosis and treatment in CAIS. Methods：Four cases of CAIS admitted to and underwent surgery in General Gynecology in Tianjin Central Hospital of Gynecology and Obstetrics from September of 2009 to October of 2012 were studied retrospectively, through analyzing and comparing medical history, clinical characteristics, hormone levels [testosterone, estradiol （Ｅ２）, luteinizing hormone （ＬＨ）, follicle stimulating hormone （ＦＳＨ）, progesterone, prolactin （ＰＲＬ） etc.], surgical findings and gonad pathological results were analysed combined with literatures. Results：All patients had a karyotype of 46, XY. Hormone levels were measured, compared with normal males, three cases had normal testosterone, one was significantly lower than the normal, four cases had elevated LH, FSH was normal in one case but higher than normal in other three cases, one in which was significantly higher than the normal; E2, progesterone, PRL were normal in four cases. One case underwent laparoscopic bilateral orchiectomy, one case underwent laparoscopic bilateral orchiectomy and perineal vaginoplasty, one case underwent bilateral orchiectomy by vulva, one case underwent laparoscopic assisted bilateral orchiectomy by inguinal. Four cases of pathologically proven after excision of the gonads were dysplasia of testicular tissue. Conclusions：Early diagnosis of CAIS is very important, patients should be treated as female social gender with gonadectomy and subsequent hormone replacement. Laparoscopy has unique advantages in the diagnosis and treatment of CAIS.

Key words: Gonadal dysgenesis, XY, Androgens, Laparoscopes, Complete androgen insensitivity syndrome