Abstract: Gestational diabetes mellitus（GDM） is one of the most important complications emerging at pregnancy. Women diagnosed with GDM is characterized by increased risk of various fetal and maternal complications which include gestational hypertension disease, premature rupture of membranes, postpartum hemorrhage and developing type Ⅱ diabetes mellitus after childbirth. At the same time, the babies are at higher risk of fetal macrosomia and deformity, neonatal asphyxia and neonatal hypoglycemia, and suffering from metabolic diseases and obesity after reaching adulthood. The routine screening for GDM begins at 24-28 weeks with a glucose challenge test. But a test method for GDM detection at the first-trimester is still lacking. With the increasing of GDM patients, early screening is getting more and more attention. Over the years, several scientists reported their new findings on early predictors of GDM. The new predictors include high-sensitivity C-reactive protein, sex hormone binding globulin, soluble pro-renin receptor, glycosylated fibronectin and galanin. This review is focused on summarizing the recent advances of these five potential predictors.

Key words: Diabetes, gestational, Biological markers, C-reactive protein, Sex hormone-binding globulin, Renin, Galanin