Abstract: Objective：To explore the relationship between homocysteine, lipid levels, CRP, NLR and Osteopenia in postmenopausal women. Methods：We collected 269 postmenopausal women from Gynecological Clinic of Hangzhou Hospital of Nanjing Medical University, who aged 45 to 60 years old, never used menopause hormone therapy. According to the bone mineral density(BMD) determination results subjects were divided into normal group (n=128) and osteopenia group (n=141). BMD was measured by dual-energy X-ray absorptiometry (DXA). Homocysteine were measured by enzyme chemiluminescence immunoassay. CRP and lipid indexes using chemiluminescence immunoassay. Results：There were significant differences between the two groups in menopause age, duration of menopause and serum levels of LDL, CRP, HCY and NLR(P＜0.05). Menopausal age, duration of menopause, LDL, CRP, HCY and NLR are risk factors in postmenopausal women with osteopenia. The odds ratios and 95% confidence intervals of those variables were found to have significant difference between the two groups(P＜0.01), and were as follows 0.755（0.623～0.914），1.408（1.043~1.901），1.038（1.018~1.058），1.398（1.115~1.753），3.534（2.355~5.303） and 3.959（2.148~7.299）. Conclusions：Menopausal age, duration of menopause, serum levels of LDL, CRP, HCY and NLR can be used as the evaluation index of bone loss in postmenopausal women.

Key words: Osteoporosis, postmenopausal, Liposomes, C-reactive protein, Neutrophils, Lymphocytes