Study on the Placental Expression of BSEP in Intrahepatic Cholestasis of Pregnancy

Journal of International Obstetrics and Gynecology ›› 2016, Vol. 43 ›› Issue (1): 42-44.

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Study on the Placental Expression of BSEP in Intrahepatic Cholestasis of Pregnancy

GU Li-ping，LIU Xiao-hui，SONG Ye，HOU Shun-yu，DAI Jian-rong

Department of Obstetrics and Gynecology，Suzhou Municipal Hospital，Suzhou 215002，Jiangsu Province，China

Received:1900-01-01 Revised:1900-01-01 Published:2016-02-15 Online:2016-02-15
Contact: DAI Jian-rong

Abstract

Abstract: Objective：To explore the expression of bile salt export pump（BSEP） in placenta tissue and its relationship with intrahepatic cholestasis of pregnancy（ICP）. Methods：The expression of BSEP in the placenta was detected by immunohistochemistry and western blotting respectively in 30 women with ICP（ICP group） and 30 normal gravidas（control group） from February 2012 to August 2013 in Department of Obstetrics of Suzhou Municipal Hospital. Results：BSEP was located at the cytoplasm in the placental trophoblastic cells. The expression of BSEP in ICP group was significantly lower than control group [（0.197 7±0.111 8） vs. （0.616 0±0.384 9），P＜0.001]. Conclusions：Decreased expression of BSEP in placenta may be associated with ICP.

Key words: Cholestasis, intrahepatic, Pregnancy, Placenta, Bile acids and salts

GU Li-ping;LIU Xiao-hui;SONG Ye;HOU Shun-yu;DAI Jian-rong. Study on the Placental Expression of BSEP in Intrahepatic Cholestasis of Pregnancy[J]. Journal of International Obstetrics and Gynecology, 2016, 43(1): 42-44.

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Study on the Placental Expression of BSEP in Intrahepatic Cholestasis of Pregnancy

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