Abstract: Recently, it has been showed in clinical, epidemiological and animal studies that maternal exposure to air fine particulate matter during pregnancy can resulted in stillbirth, abortion, fetal growth restriction, low birth weight, preterm birth and other adverse pregnancy outcomes, while the potential mechanisms is uncertain. As studies have proved, PM2.5 may cause DNA injury that leads to stillbirth, abortion and congenital abnormalities, it can also change the function of placenta to restrict fetal growth. Besides, PM2.5 exposure during pregnancy can also induce changes in the construction of placenta that may be a key point to preterm premature rupture of membrane and preterm birth. This review will provide a summary of the adverse pregnancy outcomes of PM2.5 exposure on the developing fetus.

Key words: Environmental pollution, Environmental pollutants, Air pollutants, Maternal exposure, Pregnancy outcomes, Congenital abnormalities