Abstract: Objective：To investigate the effects of Taishan Panshi San on the maternal-fetal interface Th1/Th2 cytokines and pregnancy outcomes of recurrent abortion mouse, to provide a new experimental basis for clinical application of Taishan Panshi San. Methods：Classic modeling approach DBA/2 mice CBA/J hybridization, get recurrent abortion mouse models, 60 CBA/J mice that randomly caged with DBA/2 mice were divided into model group pregnancy, low Chinese medicine dose group, middle Chinese medicine dose group, high Chinese medicine dose group and positive control group; 10 pregnant CBA/J mice mated with BALB/C as a normal pregnancy. 14 days after pregnancy pregnant rats were sacrificed to observe the mouse placenta′s missing, and to extract oocytes cultured fetal community, 24 hours latter cell supernatants were collected, Elisa assay supernatant TNF-α, IFN-γ, IL-4, IL-10 content. Results：Compare with model group, the recurrent miscarriage mouse placenta loss ratio was significantly improved after treated with Taishan Panshi San, cytokine Th1 and IFN-γ were significantly decreased in cell supernatants of mother-fetal bound, Th2 cytokines IL-4 and IL-10 were significantly increased, Th1/Th2 immunoregulatory imbalance improved significantly, the high dose Chinese tradition medicine group was the most obvious. Conclusions：Taishan Panshi San can significantly improve the placenta lost situation of recurrent abortion mouse, the specific mechanism may be achieved by adjusting the balance of Th1/Th2 immune regulation.

Key words: TAISHAN PANSHI POWDERS, Abortion, habitual, Cytokines, Th1 cells, Th2 cells