Abstract: Resistance to antineoplastic drugs is a major cause that leads to poor treatment effect in ovarian cancer. Finding effective ways of ovarian cancer chemoresistance reversal has become a hotspot at home and abroad. A rapidly growing number of recent studies shows that, overexpression of nucleus accumbens 1(NAC-1) in ovarian cancer is not only involved in pathogenesis, progression, metastasis and recurrence, but also closely related with tumor resistance. NAC-1 regulates multiple signal pathways of ovarian cancer chemoresistance to reduce anti-tumor drugs sensitivity. Therefore, the specific targeting of NAC-1 could open new avenues for reversing ovarian cancer chemoresistance, the specific inhibition of NAC-1 activity in ovarian cancer cells combined with chemotherapy is expected to be an effective cancer treatment strategy. This article reviews the mechanism of NAC-1 in ovarian cancer chemoresistance.

Key words: Nucleus accumbens 1, Nucleus accumbens, Ovarian neoplasms, Drug therapy, Drug resistance, neoplasm, Drug tolerance, Signal transduction