Abstract: Mesenchymal stem cells (MSCs) can be chemotaxis to tumor site, participate in the formation of stroma and interact with tumor cells. According to different reports, MSCs can promote ovarian cancer cells proliferation by secreting cytokines and promote tumor stem cells differentiation;different types of MSCs can interact with ovarian cancer cells and promote or inhibit the invasion and metastasis of ovarian cancer; MSCs can promote the chemotherapeutic drug resistance of ovarian cancer by activating PI3K/Akt and BMP4/HH signaling pathways; MSCs can also be used as carriers to construct a targeted drug delivery system. These results indicate that MSCs play an important role in ovarian cancer and give us new research ideas, but the specific role and mechanism is still controversial and further studies are needed. Here, we reviewed the effects and mechanisms of MSCs or modified MSCs on the growth, metastasis and chemo-resistance of ovarian cancer,our purpose is to explore new ideas for ovarian cancer treatment.

Key words: Ovarian neoplasms, Mesenchymal stem cells, Cell proliferation, Tumor invasion, Tumor metastasis