Abstract: 【Abstract】  Objective：To investigate the factors influencing the prognosis of patients with acute fatty liver of pregnancy (AFLP), and to provide a clinical basis for improving the prognosis of AFLP patients. Methods：62 patients with AFLP were retrospectively analyzed. They were divided into 2 groups, Survival group and death group, according to the prognosis. Single factor and multivariate logistic regression were used to analyze the general data and the laboratory indexes of patients. Results：There were no significantly difference between survival group and death group on red blood cell count, hematocrit, hemoglobin, platelets, total protein, total bilirubin, alanine aminotransferase, aspartate aminotransferase, albumin, direct bilirubin, creatinine, PT, Fib, APTT in plasma, and the time from treatment to termination of pregnancy time and onset to termination of pregnancy (P＜0.05). Furthermore the time during treatment to termination of pregnancy over 24 h and the time during onset to termination of pregnancy over 14 d were the risk factor on prognosis of patients with AFLP. Conclusions：The time during treatment to termination of pregnancy and the time during onset to termination of pregnancy play a key role on prognosis in AFLP.

Key words: 【Keywords】 , Pregnancy complications, Fatty liver, Maternal mortality, Logistic models, Acute fatty liver of pregnancy