Abstract: Histone lysine specific demethylase 1 (LSD1) is a kind of flavin adenine dinucleotide (FAD) dependent monoamine oxidase, which can specifically demethylate monomethylated and dimethylated K4 and K9 of histone H3 (H3K4, H3K9) as well as can specifically demethylate non histone proteins dimethylation (K370me2) at K370, which result in inhibition of p53 function by inhibiting the interaction of p53 with p53-binding protein 1(53BP1) repressing the activity of the p53 gene. In recent years, many studies have found that LSD1 plays an important role in chromatin regulation, by regulating the proliferation, invasion and metastasis of tumor cells, affecting the occurrence and development of a variety of malignant tumors. The special role of LSD1 makes it possible to become a new anti-tumor target. Nowadays, the reports about the expression of LSD1 on the role of gynecological malignancy are rare. In this paper, structure and function of LSD1 and the latest research progress of LSD1 in cervical cancer, ovarian cancer and endometrial cancer will be reviewed.

Key words: Lysine specific demethylase 1, Monoamine oxidase, Histones, Methylation, Uterine cervical neoplasms, Ovarian neoplasms, Endometrial neoplasms