Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorders in women of childbearing age characterized by sporadic ovulation or no ovulation, hyperandrogenism, insulin resistance or hyperinsulinemia. It is one of the leading causes of infertility in women of childbearing age and its pathogenesis is still not fully clear. As "the second brain of the adult", gut microbiome can interact with the brain through the brain gut axis pathway, and integrate the nerve, hormones, immune signals and other elements. Therefore, the imbalance of gut microbiome has an important relationship with metabolic diseases such as obesity, hyperlipidemia and insulin resistance. The change of gut microbiome is closely related to the pathological process of PCOS. This paper reviews the research progresses of possible mechanisms of gut microbiome in the occurrence of PCOS.

Key words: Polycystic ovary syndrome, Metabolic diseases, Insulin resistance, Enterobacteriaceae, Gut microbiome