Abstract: Endometrial repair is a common pathophysiological process in obstetrics and gynecology. It is divided into physiological endometrial repair and endometrial repair following injury. Physiological repair is the process of self-exfoliation and regeneration of the intima. It does not form scars, unlike the intimal repair, which is often incomplete. When there is an injury to the basal layer of the endometrium or destruction of the endometrial growth microenvironment，it will result in endometrial proliferation dysfunction, endometrial regeneration disorders, and even scar formation and intrauterine adhesion. These changes will affect the potential for implantation of embryos, leading to female infertility or repeated miscarriage. At present, how to promote the repair of endometrial injury still poses a great challenge. In recent years, stem cell research on endometrial repair has attracted much attention. This paper aims to review the pathophysiology of endometrial regeneration and the research progress of stem cell repair following endometrial injury.

Key words: Endometrium, Tissue adhesions, Uterus, Stem cells transplantation, Mesenchymal stromal cells