Abstract: At present, reproductive system tumors account for 15% of female systemic tumors, so there is an urgent need to find a biomarker that can guide treatment and evaluate prognosis. S100A14 protein is a member of the calcium-binding protein family and its expression is abnormal in many kinds of tumor tissues，which is closely related to the occurrence, development, invasion and metastasis of tumor. In recent years, more and more studies have shown that the expression of S100A14 is related to the clinicopathologic stage, differentiation and lymph node metastasis of gynecological tumors, and is expected to be a specific tumor marker. At present, the mechanism of S100A14 in the occurrence and development of gynecological tumors is not clear. It is accepted that S100A14 can activate the signal transduction pathway of related cells and cause the change of the expression level of related cytokines, so as to affect the normal regulation of the cell cycle. Further study on the mechanism of S100A14 in gynecological tumors and targeted intervention in the process of action can provide a new idea for clinical treatment of gynecological tumors. This article reviews the expression and mechanism of S100A14 in gynecological tumors.

Key words: S100A14 protein, Calcium-binding proteins, Genital neoplasms, female, Signal transduction, Neoplasm invasiveness, Cell proliferation