Abstract: Gestational trophoblastic neoplasia(GTN) is a group of heterogeneity related lesions caused by abnormal proliferation of placental trophoblastic cells, which can occur after full-term birth, preterm birth, miscarriage and other types of pregnancy, but its clinical manifestations are diverse. A case of trophoblastic tumor with cerebral hemorrhage as the primary manifestation is reported. The patient was admitted to hospital with cerebral hemorrhage and cerebral hernia, and was diagnosed as GTN with brain metastasis and pulmonary metastasis after completing relevant examinations. It is suggested that the possibility of brain metastasis of GTN should be considered when unexplained cerebral hemorrhage occurs in patients of reproductive age, especially those with recent pregnancy history, which has certain practical application value in clinical practice.

Key words: Gestational trophoblastic disease, Cerebral hemorrhage, Neoplasm metastasis, Drug therapy, combination