Abstract: etabolic syndrome is a serious threat to the health and quality of life of perimenopausal women. Diabetes and dyslipidemia are main parts of it，its central link is abdominal obesity and insulin resistance. Due to the decline of ovarian function, sex hormone levels of perimenopausal women have a series of changes, which have a certain impact on lipid metabolism and bone mineral density. However, the specific mechanism of women developing MS at this stage has not been fully clarified. Genetic factors and environmental factors may be related to the occurrence of MS in perimenopausal women. Individualized life style interventions and hormone replacement therapy can reduce the incidence of MS in postmenopausal women. This article reviews the relationship between female sex hormones and MS, the prevalence, treatment as well as management of MS.

Key words: Perimenopause, Metabolic syndrome X, Estrogens, Receptors, estrogen, Androgens