Abstract: Due to the sudden drop in estrogen levels, postmenopausal women are in bone reconstruction imbalance. Osteoclast function enhanced, and osteoblast function decreased. At the same time, due to the increase of age, the physiological and immune functions of postmenopausal women decrease, and the body is in chronic inflammation state for a long time. Various inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease are associated with significant local or systemic bone loss. Inflammatory factors interact with the immune system and bone remodeling, and are closely related to the progress of osteoporosis. Estrogen regulate the process of bone reconstruction, the occurrence and development of inflammation in various ways. In the past, the relationship between estrogen and osteoporosis, or inflammation and osteoporosis was usually studied separately. In recent years, there is evidence that estrogen and inflammation are interrelated in postmenopausal osteoporosis. The decline of estrogen may cause postmenopausal osteoporosis by influencing the level of inflammation and exploring how estrogen regulates inflammatory factors may provide a new theoretical basis for the treatment of osteoporosis. This article reviews estrogen and inflammatory factors in postmenopausal osteoporosis as following.

Key words: Osteoporosis, postmenopausal, Estrogens, Inflammatory factors, Inflammation mediators, Bone density