Advances in Research on Signaling Pathways Regulation of Endometriosis

doi:10.12280/gjfckx.20200508

Abstract

Abstract:

Endometriosis (EMs) is a common and difficult disease in women of childbearing age with complex pathogenesis. It is extremely invasive, easy to metastasize and relapse, and the therapeutic effect is not satisfactory. The research on the mechanism of its occurrence and development and the search for effective treatment is the focus of gynecological research. In recent years, studies have found that the processes of epithelial-mesenchymal transition, adhesion invasion and angiogenesis of ectopic endometrial cells are important mechanisms in the occurrence and development of EMs. There are many signal pathways in this process, such as transforming growth factor β (TGF-β)/Smad, Notch, nuclear factor κB (NF-κB), Wnt/β-catenin, phosphatidyl inositol 3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR). In this paper, the related signal pathways involved in the pathogenesis of EMs were described to provide a new idea for clinical prevention and treatment of EMs.

Key words: Endometriosis, Signal transduction, Wnt signaling pathway, Transforming growth factor beta, NF-kappa B, Phosphatidylinositol 3-kinases

XIE Tao, ZENG Wei-wei, LU Qi-tian, ZHOU Hua. Advances in Research on Signaling Pathways Regulation of Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(1): 1-4.

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