Abstract:

Cervical cancer is the second most common gynecological malignancy in the world, causing about 500 000 new diagnoses and 275 000 deaths each year. Nearly one-third of cervical cancer deaths are due to disease recurrence or progression. Squamous cell carcinoma is the most common type of cervical cancer. The treatment of squamous cell cervical cancer includes surgery, chemoradiotherapy and so on. And most of the known prognostic factors of squamous cell cervical cancer are evaluated after operation. Survival studies showed that the ratio of neutrophils to lymphocytes (NLR) in peripheral blood before treatment had a significant influence on the prognosis of patients with squamous cell cervical cancer after radiotherapy. And the serum squamous cell carcinoma antigen (SCC-Ag) level had a predictive effect on the recurrence, survival and lymph node metastasis of patients with squamous cell cervical cancer. NLR and SCC-Ag in peripheral blood can be easily obtained as hematological indexes. Compared with the local state of cancer reflected by International Federation of Gynecology and Obstetrics (FIGO) stage, they can better reflect the general state of patients. Also, they can be dynamically monitored from the beginning of diagnosis, which becomes reference factors for clinicians to provide the best diagnosis and treatment for patients. By elucidating the predictive value of NLR and SCC-Ag in the prognosis of cervical squamous cell carcinoma, it is expected to create a new way to analysis the progression of cervical squamous cell carcinoma.

Key words: Uterine cervical neoplasms, Carcinoma,squamous cell, Neutrophils, Lymphocytes, Antigens,neoplasm, Prognosis