Research Progress of E3 Ubiquitin Ligase CUL2 in Cervical Cancer

doi:10.12280/gjfckx.20200596

Abstract

Abstract:

Ubiquitin is an important way of post-translational regulation of proteins. As the largest E3 ubiquitin ligase family in vivo, Cullin-Ring E3 ubiquitin ligases are widely involved in regulating the degradation of cyclins and transcription factors in vivo. CUL2, as a skeleton molecule, forms the CUL2 ubiquitin ligase complex, which plays an important role in the ubiquitination degradation of von Hippel-Lindau (VHL) tumor suppressor related receptor substrates. At present, studies have found that CUL2 is generally involved in the regulation of tumor malignant transformation mechanisms such as tumor angiogenesis, cell dynamics, immune escape, cell proliferation, and epithelial mesenchymal transition. In this paper, the mechanism of CUL2 in carcinogenesis and its relationship with cervical cancer are reviewed, aiming to provide a new target for diagnosis and treatment of cervical cancer.

Key words: Uterine cervical neoplasms, Carcinoma, Ubiquitin-protein ligases, Ubiquitinated proteins, Ubiquitination, Von hippel-lindau tumor suppressor protein

ZHANG Hong-lei, ZHAO Wei-hong. Research Progress of E3 Ubiquitin Ligase CUL2 in Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2021, 48(2): 121-125.

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