Research Progress of Long Non-Coding RNA HOTAIR in Cervical Cancer

doi:10.12280/gjfckx.20210097

Abstract

Abstract:

Cervical cancer is one of the most common female reproductive system tumors in China, which seriously threatens women′s life and health. HOTAIR is a typical antisense long non-coding RNA, and its expression in cervical cancer cells is significantly increased, which is closely related to the occurrence and development of cervical cancer. In recent years, researches on the mechanism of HOTAIR in the occurrence and development of cervical cancer found that HOTAIR inhibits the expression of a large number of tumor suppressor genes, and is widely involved in the proliferation, apoptosis, invasion and migration of cervical cancer cells. HOTAIR assists the treatment of advanced cervical cancer by regulating the resistance to radiotherapy, anti-retroviral transcription and immune targeting. It plays an important role in the genetic susceptibility of cervical cancer, and has a significant correlation with tumor progression and poor prognosis. In the future, therapeutic targets will be designed according to the molecular mechanism of HOTAIR, and their effectiveness and practicability would be confirmed through large-sample, multi-center, prospective clinical trials, which will provide new ideas for the early diagnosis and personalized treatment of cervical cancer patients.

Key words: Uterine cervical neoplasms, RNA,long noncoding, HOX transcript antisense RNA, Cell proliferation, Apoptosis, Therapy

GU Xuan-yan, WANG Xin-yu. Research Progress of Long Non-Coding RNA HOTAIR in Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 620-623.

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